产品货号：
Z35160
中文名称：
p21/CDKN1A抗体
英文名称：
Anti-p21/CDKN1A Antibody (Clone#WA-1)
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-p21/CDKN1A Antibody (Clone#WA-1) |
| 指标别名 | CAP20;CDK interacting protein 1;CDKN1;CDKN1A;CIP1;MDA 6;MDA6;P21;p21CIP1;PIC1;SDI1;WAF1 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | ELISA,IF,SDS-PAGE,WB |
| 基因名称 | CDKN1A |
| 克隆号 | WA-1 |
| 抗体来源 | Mouse |
| 免疫原 | This protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human p21 fusion protein. |
| 计算分子量 | 18kDa |
| 成分 | 0.02M Potassium Phosphate,0.5M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This protein A purified mouse monoclonal antibody reacts with human and mammalian p21.The intracellular protein p21 is a 21kD protein and also known as wild-type p53-activated fragment 1 (WAF1).It is an inhibitor of cyclin-dependent kinases (Cdks) and proliferating-cell nuclear antigen (PCNA).The antibody is highly specific and shows no cross-reactivity with other closely related mitotic inhibitors. |
| 浓度 | 1.0mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | p21WAF1 is a tumor suppressor gene product critical to maintain proper regulatory control of cell division.p21WAF1 inhibits cyclin/cyclin-dependent kinase (cdk) complexes,causing cell cycle arrest by blocking cell division at the S phase.Various mutations of tumor suppressor genes have been associated with different types of cancers.In these cases,somatic gene therapy with wild-type versions of tumor suppressor genes have been contemplated as anti-cancer therapeutic approaches.p21WAF1 contains p53-binding sites in its promoter and expression of p21WAF1 is induced in WI38 fibroblasts with PMA.Anti-p21WAF1 antibody is useful for researches interested in studying tongue and gastrointestinal cancers,as well as,ubiquitin and cyclin binding proteins. |
| Uniprot ID | P38936 |
| 基因名全称 | Cyclin-dependent kinase inhibitor 1 |
| 推荐稀释比 | ELISA:1:5,000 - 1:20,000 IHC:User Optimized IF Microscopy:1:250 IP:1:100 WB:1:2,000 - 1:10,000 |
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